Sugar acids and derivatives
Medchemexpress LLC Bet-bay 002 | 1588521-78-1 | 99.8% | 403.86 g/mol | C22H18ClN5O | 10MM 1ML
BET-BAY 002 is a small-molecule inhibitor of BET family bromodomains used for epigenetic and oncology research. It has demonstrated efficacy in multiple myeloma models and is supplied in solution and solid forms suitable for biochemical and cellular assays.
- Supplied as a 10 mM solution in DMSO (1 mL) and as solid quantities.
- High purity (99.8%).
- Molecular weight 403.86 g/mol and formula C22H18ClN5O.
- Soluble in DMSO for straightforward stock preparation.
- Intended for research use in BET bromodomain inhibition and related assays.
Medchemexpress LLC Ethanone, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl | 1839150-56-9 | 98.5% | 471.55 | 25 MG
CHMFL-FLT3-122 is a potent, selective, and orally active FLT3 kinase inhibitor with an IC50 of 40 nM. It demonstrates selectivity for FLT3 over BTK (IC50 of 421 nM) and c-KIT (IC50 of 559 nM) kinases. This compound induces apoptosis by arresting the cell cycle in the G0/G1 phase. It is intended for research use only and is not sold to patients.
- Potent, selective, and orally active FLT3 kinase inhibitor
- Induces apoptosis by arresting the cell cycle into the G0/G1 phase
- Significantly inhibits proliferation of FLT3-ITD positive acute myeloid leukemia (AML) cancer cell lines (MV4-11, MOLM13/14)
- Significantly inhibits FLT3 auto-phosphorylation at Tyr589/591 site
- Inhibits phosphorylation of Stat5 ERK, AKT and expression of cMYC
- Can suppress tumor progression in animal models without significantly affecting body weight
Medchemexpress LLC [D-Trp34]-Neuropeptide Y | 153549-84-9 | 99.7% | 4311.72 | 10 MG
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. It is significantly less potent at the NPY Y1, Y2, Y4, and y6 receptors. This product markedly increases food intake in rats.
- Potent and selective neuropeptide Y (NPY) Y5 receptor agonist.
- Markedly increases food intake in rats.
Medchemexpress LLC 4-Methylumbelliferyl-β-D-glucuronide hydrate | 881005-91-0 | 99.9% | 1 ML
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrate with an excitation wavelength of 362 nm and an emission wavelength of 445 nm. This compound is used in various enzymatic reactions and has applications in detecting β-glucuronidase activity and quantifying *Escherichia coli*.
- Fluorogenic substrate with λex=362 nm and λem=445 nm
- Detects activity of β-glucuronidase
- Quantifies *Escherichia coli*
- Releases 4-methylumbelliferone in enzymatic reactions
- Suitable for kinase assays to measure GLUase activity
Medchemexpress LLC D-Glucuronic acid lactone | 32449-92-6 | MFCD00135622 | 98.0% | 176.12 | 5 G
D-Glucuronic acid lactone is an endogenous metabolite and a glucuronic acid derivative. It serves as a starting reagent for the synthesis of 2,3,4-tris (tert-butyldimethylsilyl) glucuronic acid trichloroethyl ester, which is used to prepare 1-O-acyl glucuronic acids, synthesize optically active glucuronic acids, and produce long-chain alkyl glucuronides. It also shows potential for use in studies of reversible cerebral vasoconstriction syndrome (RCVS).
- Endogenous metabolite and glucuronic acid derivative
- Starting reagent for the synthesis of specific glucuronic acid esters
- Prepares 1-O-acyl glucuronic acids
- Synthesizes optically active glucuronic acids
- Produces long-chain alkyl glucuronides
- Potential use in studies of reversible cerebral vasoconstriction syndrome (RCVS)
Medchemexpress LLC Integrin alpha V bet 50ug
Integrin V beta 5 proteins specifically the -V (ITGAV) subunit are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences ITGAV ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling Integrin alpha V beta 8 Protein Human (HEK293 His solution) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 8 protein expressed by HEK293 with C-His labeled tag Integrin alpha V beta 8 Protein Human (HEK293 His solution) has molecular weight of 187 95 kDa
Medchemexpress LLC Cdk1/Cyc B-IN-1 | 2459916-56-2 | 98.5% | 353.85 | 50 MG
CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. It triggers apoptosis and G2/M cell cycle arrest and demonstrates broad-spectrum cytotoxic action against cancer cell lines. In vitro, it is soluble in DMSO at 100 mg/mL.
- Induces apoptosis and G2/M cell cycle arrest
- Exhibits cytotoxic activity against HCT-116 cells (IC50 of 5.33 ± 0.69 μM)
- Exhibits cytotoxic activity against WI-38 cells (IC50 of 21.69 ± 1.04 μM)
- Shows antiproliferative activity against various human cancer cell lines
Medchemexpress LLC 4-Methylumbelliferyl 10mM 1mL
4-Methylumbelliferyl octanoate is a octoate 4-Methylumbelliferyl octanoate can be used as a s ubstrate of hog pancreatic lipase[1]
Medchemexpress LLC Integrin alpha V beta 5 protein | >95.0% | 20UG
Integrin alpha V beta 5 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant human integrin αVβ5 dimer expressed in HEK293 cells and supplied biotinylated with C-Avi and C-His tags. It is provided in microgram quantities and intended for receptor-ligand interaction studies, biochemical assays, and biophysical analyses that require the native extracellular domains.
- Biotinylated C-Avi and C-terminal His tags for detection and capture
- Expressed in HEK293 cells to preserve mammalian post-translational modifications
- High purity >95% as determined by reducing SDS-PAGE
- Molecular weight range 85-140 kDa consistent with heterodimeric extracellular domains
- Available in multiple microgram sizes to suit different assay scales
Medchemexpress LLC Perindopril acyl-β-D-glucuronide | 120398-66-5 | 544.59 | 1 MG
Perindopril acyl-β-D-glucuronide is a metabolite of Perindopril, which is an ACE inhibitor. This product is intended for research purposes only.
- For research use only.
- Not for sale to patients.
Medchemexpress LLC Integrin alpha V bet 100ug | 100ug
Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein expressed by HEK293 with C-His C-Avi labeled tag Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) has molecular weight of 90-150 kDa
Apexbio Technology LLC Cytochalasin D 22144-77-0 10mg
Cytochalasin D is a selective inhibitor of actin polymerization with a reported IC50 value of approximately 25 nM It exerts its biological effect by disrupting the formation and stability of actin filaments thereby influencing cellular processes dependent on cytoskeletal organization Through this mechanistic action Cytochalasin D induces cell cycle arrest at the G1-S transition via activation of p53-related signaling pathways In neuronal studies treatment with Cytochalasin D interferes with filopodial and lamellipodial dynamics by limiting protrusion elongation Additionally in vitro investigations demonstrated its utility in the study of virus-host interactions where blockade of actin polymerization inhibits pathogen entry and replication making Cytochalasin D a relevant reagent in cellular biology and virology research
Medchemexpress LLC Integrin alpha V beta 3 protein, mouse (HEK293, His) | >95.0% | 50UG
Integrin alpha V beta 3 protein, mouse (HEK293, His) is a recombinant heterodimeric integrin complex produced in HEK293 cells and supplied with a C-terminal His tag. It is intended for research use to support studies of integrin-mediated cell adhesion, signaling, and ligand interactions.
- Recombinant heterodimeric integrin complex (ITGAV:ITGB3).
- Expressed in HEK293 mammalian cells.
- C-terminal His tag for detection and purification.
- Purity greater than 95% as determined by reducing Tris-Bis PAGE.
- Observed molecular weight 90-130 kDa.
- Available in small-scale sizes suitable for biochemical assays (20 μg, 50 μg, 100 μg).
- For research use only; not for therapeutic or diagnostic use.